Basic Information

Gene symbol IL13RA2 Synonyms CD213A2, CT19, IL-13R, IL13BP Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description interleukin 13 receptor subunit alpha 2

GTO ID GTC0214
Trial ID NCT02208362
Disease Glioblastoma
Altered gene IL13RA2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment IL13R alpha 2 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleGenetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma
Year2014
CountryUnited States
Company sponsorCity of Hope Medical Center
Other ID(s)13384|NCI-2014-01488|13384|P30CA033572|R01FD005129
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Vector typeself-inactivating lentiviral vector
Transgene/Inserted genemembrane-tethered human IL-13 ligand mutated at a single site; human CD4 transmembrane domain; human costimulatory 4-1BB cytoplasmic signaling domain; human CD3ζ cytoplasmic signaling domain

Clinical Result

Cohort1: ICT biopsy_Tcm
Administration route None
Dosage 2E6 cells, 10E6 cells
Donor type Autologous
Pts 2
Age Child, Adult, Older_Adult
References PMID: 38454126
Cohort2: ICT resection_Tcm
Administration route None
Dosage 2E6 cells, 10E6 cells, 50E6 cells, 20E6 cells, 100E6 cells
Donor type Autologous
Pts 18
Age Child, Adult, Older_Adult
References PMID: 38454126
Cohort3: ICV_Tcm
Administration route None
Dosage 2E6 cells, 10E6 cells, 50E6 cells, 20E6 cells, 100E6 cells
Donor type Autologous
Pts 11
Age Child, Adult, Older_Adult
References PMID: 38454126
Cohort4: dual ICT/ICV_Tcm
Administration route None
Dosage 2E6 cells, 10E6 cells, 50E6 cells
Donor type Autologous
Pts 12
Age Child, Adult, Older_Adult
References PMID: 38454126
Cohort5: dual ICT/ICV_Tn/mem
Administration route None
Dosage 2E6 cells, 10E6 cells, 50E6 cells, 20E6 cells, 100E6 cells
Donor type Autologous
Pts 22
Age Child, Adult, Older_Adult
Outcome 1/21(CR); 10/21(SD); 10/21(PD); Median overall survival:10.2 months
References PMID: 38454126

Relationship Graph

Overview of Knowledge Graph