Basic Information

Gene symbol MAGEA1 Synonyms CT1.1, MAGE1 Type of gene protein-coding
Description MAGE family member A1

Gene symbol MAGEA3 Synonyms CT1.3, HIP8, HYPD, MAGE3, MAGEA6 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description MAGE family member A3

GTO ID GTC0207
Trial ID NCT02153905
Disease Renal Carcinoma | Melanoma | Bladder Cancer | Breast Cancer | Cervical Cancer
Altered gene MAGE-A3|MAGE-A1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment MAGE-A1/A3 TCR-T cells
HLAHLA-A*01
PhasePhase1|Phase2
Recruitment statusTerminated
TitleA Phase I-II Study of the Treatment of Metastatic Cancer That Expresses MAGE-A3 Using Lymphodepleting Conditioning Followed by Infusion of Anti-MAGE-A3 HLA-A*01 Restricted TCR-Gene Engineered Lymphocytes and Aldesleukin
Year2014
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)140110|14-C-0110
Vector information
Vectorretrovirus
Transgene/Inserted geneanti-MAGE-A3 gene

Clinical Result

Cohort1: dose level 1
Administration route infusion
Dosage 1E9 cells
Donor type autologous
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 0/1(ORR)
Adverse reactions 1/1(All couse mortality); 1/1(Gastrointestinal disorders; General disorders; General disorders; Infections and infestations; Nervous system disorders; Nervous system disorders; Vascular disorders)
Cohort2: dose level 2
Administration route infusion
Dosage 1E8 cells
Donor type autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/2(PR)
Adverse reactions 1/2(Infections and infestations)

Relationship Graph

Overview of Knowledge Graph