Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0205
Trial ID NCT02146924
Disease Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19CAR-CD28-CD3zeta-EGFRt-expressing T cell
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleCellular Immunotherapy in Treating Patients With High-Risk Acute Lymphoblastic Leukemia
Year2014
CountryUnited States
Company sponsorCity of Hope Medical Center
Other ID(s)13447|NCI-2014-01060|120202|111660|109630|113660|13447/115692|118097|13447
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ
Additional featureEGFRt

Clinical Result

Cohort1: Tcm-enriched T cell
Administration route None
Pts 71
Age Adult, Older_Adult
References DOI: 10.1182/blood-2022-163439
Cohort2: Tn/nem-enriched T cell
Administration route None
Pts 46
Age Adult, Older_Adult
Outcome 87%(CR); 2%(PD)
References DOI: 10.1182/blood-2022-163439

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