Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0202
Trial ID NCT02132624
Disease B-Cell Leukemia | B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation3rd
PhasePhase1|Phase2
Recruitment statusCompleted
TitleCD19-targeting 3rd Generation CAR T Cells for Refractory B Cell Malignancy - a Phase I/IIa Trial.
Year2014
CountrySweden
Company sponsorUppsala University
Other ID(s)003:TCELL|2013-001393-19
Vector information
Vectorretrovirus
ConstructscFv-CD28-4-1BB-CD3ζ
Transgene/Inserted geneCD19 targeting antibody scFv; signaling domains derived from CD3 zeta, CD28 and 4-1BB

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2E7~E8 cells/m^2
Donor type Autologous
Pts 15
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 6/15(CR); 2/15(SD); 7/15(PD)
Adverse reactions 3/15(cytokine release syndrome), 2/15(central nervous system toxicity)
References PMID: 30097433

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