Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0192
Trial ID NCT02062359
Disease Metastatic Melanoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment NY-ESO-1 TCR-T cells
HLAHLA-A*02:01
PhasePhase2
Recruitment statusTerminated
TitlePhase II Study of CD62L+-Derived T Lymphocytes Transduced With a T Cell Receptor Recognizing the NY-ESO-1 Antigen and Aldesleukin Following Lymphodepletion in Patients With NY-ESO-1 Expressing Melanoma
Year2014
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)140058|14-C-0058
Vector information
Vectorretrovirus
Transgene/Inserted geneanti-ESO-1 gene

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 0/2(ORR)
Adverse reactions none(grade 3 or higher)

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