Basic Information

Gene symbol MAGEA3 Synonyms CT1.3, HIP8, HYPD, MAGE3, MAGEA6 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description MAGE family member A3

Gene symbol MAGEC1 Synonyms CT7, CT7.1 Type of gene protein-coding
Description MAGE family member C1

Gene symbol WT1 Synonyms AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description WT1 transcription factor

GTO ID GTC0191
Trial ID NCT01995708
Disease Myeloma
Altered gene MAGE-C1|MAGE-A3|WT1
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment LC Vaccine
PhasePhase1
Recruitment statusCompleted
TitleA Phase I Trial of Vaccination With CT7, MAGE-A3, and WT1 mRNA-electroporated Autologous Langerhans-type Dendritic Cells as Consolidation for Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
Year2014
CountryUnited States
Company sponsorMemorial Sloan Kettering Cancer Center
Other ID(s)13-009
Vector information
Vectorlangerhans cell

Clinical Result

Cohort1: LC vaccines
Administration route intradermal injection
Dosage LC vaccines, 9E6 LCs per vaccine, 3 vaccinations
Pts 13
Age Adult, Older_Adult
Outcome Number of Participants Evaluated for Vaccine Safety:Measure Type: Count of Participants:13(100.0%)
Adverse reactions 12/13(All-cause mortality); 3/13(Cardiac disorders; Gastrointestinal disorders; Metabolism and nutrition disorders; Respiratory, thoracic and mediastinal disorders)
References PMID: 35100339
Cohort2: Standard of care
Administration route None
Pts 15
Age Adult, Older_Adult
Outcome Number of Participants Evaluated for Vaccine Safety:Measure Type: Count of Participants:15(100.0%)
Adverse reactions 8/15(All-cause mortality); 2/15(Infections and infestations; Vascular disorders)
References PMID: 35100339

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