Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0188
Trial ID NCT01967823
Disease Meningioma | Hepatocellular Carcinoma | Lung Non-Small Cell Carcinoma | Melanoma | Breast Cancer
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment NY-ESO-1 TCR-T cells
HLAHLA-A*02:01
PhasePhase2
Recruitment statusCompleted
TitlePhase II Study of Metastatic Cancer That Expresses NY-ESO-1 Using Lymphodepleting Conditioning Followed by Infusion of Anti-NY ESO-1 Murine TCR-Gene Engineered Lymphocytes
Year2013
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)130214|13-C-0214
Vector information
Vectorretrovirus
Transgene/Inserted geneanti-ESO-1 gene

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Pts 11
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 1/10(CR); 5/10(PR)
Adverse reactions 8/11(All-cause mortality); 4/11(Blood and lymphatic system disorders; Cardiac disorders; Infections and infestations; Metabolism and nutrition disorders; Nervous system disorders; Psychiatric disorders; Renal and urinary disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)

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