Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0173
Trial ID NCT01864889
Disease Mantle Cell Lymphoma | Follicular Lymphoma | Diffuse Large B-Cell Lymphoma | Prolymphocytic Leukemia | Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
Recruitment statusUnknown
TitleTreatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by CART19
Year2013
CountryChina
Company sponsorChinese PLA General Hospital
Other ID(s)CHN-PLAGH-BT-005
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route infusion
Dosage 2.53E6 cells/kg
Donor type Autologous
Pts 9
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 6/9(CR); 3/9(PR)
Adverse reactions 3/9(grade 4 or higher adverse reactions)
References PMID: 29599530 | 26451310

Relationship Graph

Overview of Knowledge Graph