Basic Information

Gene symbol HSPB1 Synonyms CMT2F, HEL-S-102, HMN2B, HMND3, HS.76067, HSP27, HSP28, Hsp25, SRP27 Type of gene protein-coding
Description heat shock protein family B (small) member 1

GTO ID GTC0169
Trial ID NCT01844817
Disease Pancreatic Cancer
Altered gene Hsp27
Therapeutic/Target gene Target gene
TherapyASO
Treatment OGX-427|Apatorsen
PhasePhase2
Recruitment statusCompleted
TitleA Randomized, Double-Blinded, Placebo-Controlled Phase II Trial Of Gemcitabine Plus Nab-Paclitaxel Combined With OGX-427 Or Placebo In Patients With Metastatic Pancreatic Cancer (The Rainier Trial)
Year2013
CountryUnited States
Company sponsorSCRI Development Innovations, LLC
Other ID(s)SCRI GI 184
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 600 mg, three loading doses within a 9-day period, then 600 mg on Days 1, 8, 15 and 22 ofEach 28-day cycle
Pts 66
Age Adult, Older_Adult
Outcome 0/66(CR); 18/66(PR)
Adverse reactions 64/64(Blood and lymphatic system disorders; Cardiac disorders; Gastrointestinal disorders; General disorders; Hepatobiliary disorders; Hepatobiliary disorders; Infections and infestations; Metabolism and nutrition disorders; Nervous system disorders; Renal and urinary disorders; Respiratory, thoracic and mediastinal disorders; Skin and subcutaneous tissue disorders; Vascular disorders)
References PMID: 28935773

Relationship Graph

Overview of Knowledge Graph