Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0168
Trial ID NCT01840566
Disease Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Co-treatment Carmustine|Etoposide|Cytarabine|Melphalan|Pegfilgrastim
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleHigh Dose Therapy and Autologous Stem Cell Transplantation Followed by Infusion of Chimeric Antigen Receptor (CAR) Modified T-Cells Directed Against CD19+ B-Cells for Relapsed and Refractory Aggressive B Cell Non-Hodgkin Lymphoma
Year2013
CountryUnited States
Company sponsorMemorial Sloan Kettering Cancer Center
Other ID(s)12-117
Vector information
Vectorretrovirus
ConstructscFv-CD28-CD3ζ
Transgene/Inserted geneT-cell CD3ζ chain; CD28 domain

Clinical Result

Cohort 1
Administration route infusion
Dosage 5E6 cells/kg, 1E7 cells/kg, 2E7 cells/kg
Donor type Autologous
Pts 15
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 8/15(CR); 2/15(SD)
Adverse reactions 10/15(neurotoxicity; cytokine release syndrome)
References PMID: 31262783

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