Basic Information

Gene symbol STAT3 Synonyms ADMIO, ADMIO1, APRF, HIES Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description signal transducer and activator of transcription 3

GTO ID GTC0167
Trial ID NCT01839604
Disease Hepatocellular Carcinoma
Altered gene STAT3
Therapeutic/Target gene Target gene
TherapyASO
Treatment ISIS-STAT3rx|AZD9150|ISIS 481464|IONIS-STAT3-2.5Rx
PhasePhase1
Recruitment statusCompleted
TitleA Phase I/Ib, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9150 in Patients With Advanced/Metastatic Hepatocellular Carcinoma
Year2013
CountryChina|Japan|Korea, Republic of
Company sponsorAstraZeneca
Other ID(s)D5660C00001|ISIS 481464
Vector information
VectorNo vector was used

Clinical Result

Cohort1: AZD9150_dose level1
Administration route intravenous infusion
Dosage AZD9150, 1mg/kg
Age Adult, Older_Adult
Adverse reactions no AZD9150 related Adverse reactions
Cohort2: AZD9150_dose level2
Administration route intravenous infusion
Dosage AZD9150, 1.5mg/kg
Age Adult, Older_Adult
Adverse reactions no AZD9150 related Adverse reactions
Cohort3: AZD9150_dose level3
Administration route intravenous infusion
Dosage AZD9150, 2mg/kg
Age Adult, Older_Adult
Adverse reactions 2/7(Gastrointestinal disorders; Infections and infestations)
Cohort4: AZD9150_dose level4
Administration route intravenous infusion
Dosage AZD9150, 2.5mg/kg
Age Adult, Older_Adult
Adverse reactions 2/5(Gastrointestinal disorders; Hepatobiliary disorders)
Cohort5: AZD9150_dose level5
Administration route intravenous infusion
Dosage AZD9150, 3mg/kg
Age Adult, Older_Adult
Adverse reactions 4/15(Blood and lymphatic system disorders; Gastrointestinal disorders; Infections and infestations)

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