Basic Information

Gene symbol MET Synonyms AUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description MET proto-oncogene, receptor tyrosine kinase

GTO ID GTC0166
Trial ID NCT01837602
Disease Sporadic Breast Cancer | Triple-Receptor Negative Breast Cancer
Altered gene c-MET
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment cMet CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusCompleted
TitleCMet CAR RNA T Cells Targeting Breast Cancer
Year2013
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 13111, 813858

Clinical Result

Cohort 1
Administration route intratumoral injection
Dosage 3E7~E8 cells
Donor type Autologous
Pts 6
Age Adult, Older_Adult
Lymph depletion No
Adverse reactions no any CAR-T-related severe events
References PMID: 29109077

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