Basic Information

Gene symbol MIR34A Synonyms MIRN34A, miRNA34A, mir-34, mir-34a Type of gene ncRNA
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description microRNA 34a

GTO ID GTC0164
Trial ID NCT01829971
Disease Lung Non-Small Cell Carcinoma | Liver Cancer | Melanoma | Multiple Myeloma | Renal Cell Carcinoma | Lung Small Cell Carcinoma | Lymphoma
Altered gene miR-34a
Therapeutic/Target gene Target gene
TherapymiRNA
Treatment MRX34
Co-treatment dexamethasone (DEX)
PhasePhase1
Recruitment statusTerminated
TitleA Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection
Year2013
CountryKorea,Republic of|United States
Company sponsorMirna Therapeutics, Inc;Cancer Prevention Research Institute of Texas
Other ID(s)MRX34-101
Vector information
Vectorlipid nanoparticle

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage MRX34, 50~110mg/m^2, daily for 5 days, followed by 2 weeks of rest in 3-week cycles (QDx5 schedule)
Pts 155
Age Adult, Older_Adult
Outcome 3/85(PR); 49/85(SD); 31/85(PD)
References PMID: 32238921

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