Basic Information

Gene symbol HSPB1 Synonyms CMT2F, HEL-S-102, HMN2B, HMND3, HS.76067, HSP27, HSP28, Hsp25, SRP27 Type of gene protein-coding
Description heat shock protein family B (small) member 1

GTO ID GTC0163
Trial ID NCT01829113
Disease Lung Non-Squamous Non-Small Cell Carcinoma
Altered gene Hsp27
Therapeutic/Target gene Target gene
TherapyASO
Treatment OGX-427|Apatorsen
PhasePhase2
Recruitment statusCompleted
TitleDouble-Blind Randomized Phase II Trial of Carboplatin and Pemetrexed With or Without OGX-427 in Patients With Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer (The Spruce Clinical Trial)
Year2013
CountryUnited States
Company sponsorSCRI Development Innovations, LLC
Other ID(s)SCRI LUN 229
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 600 mg, three loading doses within a 9-day period, then 600 mg on Days 1, 8 and 15 ofEach 21-day cycle
Pts 77
Age Adult, Older_Adult
Adverse reactions 56/77(All-cause mortality); 35/74(Blood and lymphatic system disorders; Cardiac disorders; Gastrointestinal disorders; General disorders; Hepatobiliary disorders; Infections and infestations; Infections and infestations; Metabolism and nutrition disorders; Nervous system disorders; Psychiatric disorders; Psychiatric disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)

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