Basic Information

Gene symbol HSPB1 Synonyms CMT2F, HEL-S-102, HMN2B, HMND3, HS.76067, HSP27, HSP28, Hsp25, SRP27 Type of gene protein-coding
Description heat shock protein family B (small) member 1

GTO ID GTC0162
Trial ID NCT01780545
Disease Bladder Cancer | Urothelial Carcinoma
Altered gene Hsp27
Therapeutic/Target gene Target gene
TherapyASO
Treatment OGX-427|Apatorsen
PhasePhase2
Recruitment statusCompleted
TitleThe Borealis-2 Clinical Trial: A Randomized Phase 2 Study Comparing Docetaxel Alone to Docetaxel in Combination With OGX-427 in Patients With Relapsed or Refractory Metastatic Urothelial Carcinoma After Receiving a Platinum-containing Regimen: Hoosier Cancer Research Network GU12-160
Year2013
CountryUnited States
Company sponsorNoah Hahn, M.D.
Other ID(s)GU12-160
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 600 mg, three loading doses within a 9-day period, then 600 mg on Days 1, 8 and 15 ofEach 21-day cycle
Pts 99
Age Adult, Older_Adult
Adverse reactions 78/99(All-cause mortality); 56/99(Blood and lymphatic system disorders; Cardiac disorders; Gastrointestinal disorders; General disorders; Infections and infestations; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders; Neoplasms benign, malignant and unspecified, incl cysts and polyps; Nervous system disorders; Psychiatric disorders; Renal and urinary disorders; Reproductive system and breast disorders; Vascular disorders)

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