Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0155
Trial ID NCT01697527
Disease Synovial Sarcoma | Melanoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment NY-ESO-1 TCR-T cells
Co-treatment dendritic cell vaccine therapy|fludeoxyglucose F 18
HLAHLA-A*02:01
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleAdoptive Transfer of NY-ESO-1 TCR Engineered Peripheral Blood Mononuclear Cells (PBMC) After a Nonmyeloablative Conditioning Regimen, With Administration of NY-ESO-1157-165 Pulsed Dendritic Cells and Interleukin-2, in Patients With Advanced Malignancies
Year2012
CountryUnited States
Company sponsorJonsson Comprehensive Cancer Center
Other ID(s)12-000153|NCI-2012-01548
Vector information
Vectorretrovirus

Clinical Result

Cohort1: synovial sarcoma
Administration route infusion
Dosage 1E9 cells
Donor type autologous
Pts 2
Age Child, Adult, Older_Adult
Lymph depletion Yes
Adverse reactions none(grade 3 or higher)
References PMID: 30573690
Cohort2: melanoma
Administration route infusion
Dosage 1E9 cells
Donor type autologous
Pts 2
Age Child, Adult, Older_Adult
Lymph depletion Yes
Adverse reactions none(grade 3 or higher)
References PMID: 30573690

Relationship Graph

Overview of Knowledge Graph