Basic Information

Gene symbol HSPB1 Synonyms CMT2F, HEL-S-102, HMN2B, HMND3, HS.76067, HSP27, HSP28, Hsp25, SRP27 Type of gene protein-coding
Description heat shock protein family B (small) member 1

GTO ID GTC0153
Trial ID NCT01681433
Disease Prostate Cancer
Altered gene Hsp27
Therapeutic/Target gene Target gene
TherapyASO
Treatment OGX-427|Apatorsen
Co-treatment Abiraterone Acetate|Prednisone
PhasePhase2
Recruitment statusTerminated
TitleThe Pacific Clinical Trial: A Randomized Phase II Study Evaluating OGX-427 in Patients With Metastatic Castrate-Resistant Prostate Cancer (MCRPC)Who Have Prostate-Specific Antigen (PSA) Progression While Receiving Abiraterone: Hoosier Oncology Group GU12-159
Year2012
CountryCanada|United States
Company sponsorCostantine Albany
Other ID(s)GU12-159
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Pts 56
Age Adult, Older_Adult
Outcome 1/33(PR); 23/33(PD); 6/33(SD)
Adverse reactions 8/56(All-cause mortality); 12/56(Gastrointestinal disorders; General disorders; Infections and infestations; Injury, poisoning and procedural complications; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders; Psychiatric disorders; Renal and urinary disorders; Respiratory, thoracic and mediastinal disorders)

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