Detail

Basic Information Clinical Results Relationship Graph

Gene symbol	EIF4E	Synonyms	AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E	Type of gene	protein-coding
Chromosome	4	Map location	4q23	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas \| PertOrg
Description	eukaryotic translation initiation factor 4E

GTO ID	GTC0152
Trial ID	NCT01675128
Disease	Colorectal Carcinoma
Altered gene	EIF4E
Therapeutic/Target gene	Target gene
Therapy	ASO
Treatment	ISIS 183750
Phase	Phase1\|Phase2
Recruitment status	Completed
Title	A Phase I/II Study of ISIS 183750 in Combination With Irinotecan in Irinotecan-refractory Colorectal Cancer
Year	2012
Country	United States
Company sponsor	National Cancer Institute (NCI)
Other ID(s)	120187\|12-C-0187

Vector information

Vector	No vector was used

Cohort1: Irinotecan_dose level 1_ISIS 183750_dose level 1

Administration route	intravenous injection
Dosage	Irinotecan, 160 mg/m^2, every other week; ISIS 183750, started 800 mg/every week
Pts	4
Age	Adult, Older_Adult
Adverse reactions	3/4(Endocrine disorders; Gastrointestinal disorders; General disorders; Infections and infestations; Vascular disorders)

Cohort2: Irinotecan_dose level 2_ISIS 183750_dose level 2

Administration route	intravenous injection
Dosage	Irinotecan, 180 mg/m^2 every other week; ISIS 183750, 1000 mg/every week, Cycle 1 Days 1, 3, 5, 8, 15 and 22 of a 28 day cycle, restaged every 8 weeks
Pts	10
Age	Adult, Older_Adult
Adverse reactions	3/10(Blood and lymphatic system disorders; Gastrointestinal disorders; Metabolism and nutrition disorders; Vascular disorders)

Cohort3: Irinotecan_dose level 1_ISIS 183750_dose level 2

Administration route	intravenous injection
Dosage	Irinotecan 160 mg/m^2, every other week; ISIS 183750, 1000mg every week without break, Days 1, 8, 15 and 22 of a 28-day cycle. Patients will be re-staged every 8 weeks
Pts	10
Age	Adult, Older_Adult
Adverse reactions	4/10(Blood and lymphatic system disorders; Gastrointestinal disorders; General disorders; Infections and infestations; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders; Nervous system disorders; Psychiatric disorders; Renal and urinary disorders; Vascular disorders)

Overview of Knowledge Graph