Basic Information

Gene symbol WT1 Synonyms AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description WT1 transcription factor

GTO ID GTC0148
Trial ID NCT01621724
Disease Acute Myeloid Leukemia | Chronic Myeloid Leukemia
Altered gene WT1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment WT1 TCR-T cells
HLAHLA-A*02:01
PhasePhase1|Phase2
Recruitment statusCompleted
TitleWT1 TCR Gene Therapy for Leukaemia: A Phase I/II Safety and Toxicity Study
Year2012
CountryUnited Kingdom
Company sponsorCell Medica Ltd
Other ID(s)D-00272-CT2014001|2006-004950-25
Vector information
Vectorretrovirus
Transgene/Inserted genethe genes for a WT1-specific, HLA-A2-restricted T cell receptor

Clinical Result

Cohort1: dose level 1
Administration route intravenous infusion
Dosage ≤ 2E7 cells/kg
Donor type autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/3(CR)
Adverse reactions 2/3(Blood and lymphatic system disorders)
Cohort2: dose level 2
Administration route intravenous infusion
Dosage ≤ 1E8 cells/kg
Donor type autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 3/4(CR)
Adverse reactions No serious clinical adverse events

Relationship Graph

Overview of Knowledge Graph