Basic Information

Gene symbol TYR Synonyms ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description tyrosinase

GTO ID GTC0145
Trial ID NCT01586403
Disease Melanoma
Altered gene TYR
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment TIL 1383I TCR-T cells
HLAHLA-A*02
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleTransfer of Genetically Engineered Lymphocytes in Melanoma Patients: A Phase 1 Dose Escalation Study
Year2012
CountryUnited States
Company sponsorLoyola University
Other ID(s)203732|R44CA126461|P01CA154778
Vector information
Vectorlentivirus
Vector typeGMP-grade replication-deficient lentivirus vector
Transgene/Inserted geneCD34t
Vector production methodActivated T cells were transduced by spinoculation for 2 h at 2000×g with a GMP-grade replication-deficient lentivirus carrying the TIL1383I TCR and CD34t genes. Transduced T cells were cultured 4 days then isolated by CD34-selection using the CliniMACS cell selector.

Clinical Result

Cohort 1
Administration route infusion
Dosage 2.27~2.87E8 cells
Donor type autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/3(PR); 1/3(CR)
Adverse reactions 2/3(vitiligo)
References PMID: 29052782

Relationship Graph

Overview of Knowledge Graph