Basic Information

Gene symbol IL12A Synonyms CLMF, IL-12A, NFSK, NKSF1, P35 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 12A

Gene symbol IL12B Synonyms CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2 Type of gene protein-coding
Description interleukin 12B

GTO ID GTC0143
Trial ID NCT01579318
Disease Primary Cutaneous T-Cell Non-Hodgkin's Lymphoma
Altered gene IL-12A|IL-12B
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment pIL-12
PhasePhase2
Recruitment statusTerminated
TitleA Multicenter Phase II Trial of Intratumoral IL12 Plasmid Electroporation in Cutaneous Lymphoma
Year2012
CountryUnited States
Company sponsorOncoSec Medical Incorporated
Other ID(s)OMS-I120
Vector information
Vectorplasmid

Clinical Result

Cohort 1
Administration route intratumoral injection
Dosage 1.0 mg/mL, 4 cycles of treatment (3 daily treatments on Days 1, 5 and 8, in a 12-week cycle)
Pts 2
Age Adult, Older_Adult
Outcome 1/2(ORR)
Adverse reactions No serious clinical adverse events

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