Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC0142
Trial ID NCT01573572
Disease Age-Related Macular Degeneration | Diabetic Macular Edema | Retinal Vein Occlusion
Altered gene VEGFA
Therapeutic/Target gene Target gene
TherapyAptamer
Treatment Macugen|pegaptanib|EYE001
PhasePhase4
Recruitment statusCompleted
TitleA Phase IV, Open Label, Multi-center Study to Assess the Effect of Intravitreal Injections of Macugen (Pegaptanib Sodium Injection) Administered Every 6 Weeks for 48 Weeks on the Corneal Endothelium
Year2007
CountryUnited States
Company sponsorBausch & Lomb Incorporated
Other ID(s)EOP 1024

Clinical Result

Cohort 1
Administration route intravitreal injection
Dosage Macugen, 0.3mg, every 6 weeks for 48 weeks
Pts 131
Age Adult, Older_Adult
Outcome Change From Baseline in Mean Endothelial Cell Density:Mean (Standard Deviation):-35.86(175.544)
Adverse reactions 4/131(All-cause mortality); 12/131(Cardiac disorders; Eye disorders; Gastrointestinal disorders; General disorders; Infections and infestations; Metabolism and nutrition disorders; Psychiatric disorders; Renal and urinary disorders; Vascular disorders)

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