Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0141
Trial ID NCT01567891
Disease Ovarian Cancer
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment NY-ESO-1 TCR-T cells
HLAHLA-A*02:01|HLA-A*02:05|HLA-A*02:06
PhasePhase2
Recruitment statusCompleted
TitleA Phase I/IIa, Open Label Clinical Trial Evaluating the Safety and Efficacy of Autologous T Cells Expressing Enhanced TCRs Specific for NY-ESO-1 in Patients With Recurrent or Treatment Refractory Ovarian Cancer.
Year2012
CountryUnited States
Company sponsorAdaptimmune
Other ID(s)ADP-0011-001|230612

Clinical Result

Cohort 1
Administration route infusion
Dosage 1~6E9 cells
Donor type autologous
Pts 6
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 0/6(Tumor Response)
Adverse reactions 6/6(All-cause mortality); 5/6(Blood and lymphatic system disorders; General disorders; Immune system disorders; Metabolism and nutrition disorders; Nervous system disorders)

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