Basic Information

Gene symbol FURIN Synonyms FUR, PACE, PCSK3, SPC1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description furin, paired basic amino acid cleaving enzyme

Gene symbol TGFB1 Synonyms CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description transforming growth factor beta 1

Gene symbol TGFB2 Synonyms G-TSF, LDS4, TGF-beta2 Type of gene protein-coding
Description transforming growth factor beta 2

GTO ID GTC0139
Trial ID NCT01551745
Disease Ovarian Cancer
Altered gene FURIN|TGFB1|TGFB2
Therapeutic/Target gene Target gene
TherapyshRNA
Treatment Vigil|FANG Vaccine
Co-treatment Bevacizumab
PhasePhase2
Recruitment statusCompleted
TitlePhase II Trial of Adjuvant Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Vaccine (FANG) Integrated With Bevacizumab for Patients With Recurrent/Refractory Ovarian Cancer Participating in Study CL-PTL 105
Year2012
CountryUnited States
Company sponsorGradalis, Inc
Other ID(s)CL-PTL 112

Clinical Result

Cohort 1
Administration route cells/intradermal injection|intravenous injection
Dosage Vigil, 1.0E7 cells, one day, each cycle for a maximum of 12 doses
Pts 5
Age Adult, Older_Adult
Outcome Time to Progression:Overall Number of Participants Analyzed:0|Response Rate:Overall Number of Participants Analyzed:0
Adverse reactions 4/5(All-cause mortality); 3/5(Hepatobiliary disorders; Infections and infestations; Nervous system disorders)

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