Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0114
Trial ID NCT01350401
Disease Melanoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment NY-ESO-1 TCR-T cells
HLAHLA-A*02:01
PhasePhase1|Phase2
Recruitment statusTerminated
TitlePhase I/II Study to Assess the Safety and Activity of Enhanced TCR Transduced Autologous T Cells in Metastatic Melanoma
Year2011
CountryUnited States
Company sponsorAdaptimmune
Other ID(s)ADP 01611
Vector information
Vectorlentivirus
ConstructNY-ESO-1c259T cells
Transgene/Inserted geneCTAG1B
Regulatory elementEF1α promoter; a Woodchuck hepatitis virus post-translational regulatory element (WPRE)
Vector production methodLentiviral vector was produced at the City of Hope (Duarte, CA) using transient transfection with four plasmids expressing the transfer vector, Rev, VSV-G and gag/pol, in 293T cells.

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.5~1E10 cells
Donor type autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 0/4(Tumor Response)
Adverse reactions 3/4(All-cause mortality); 4/4(Blood and lymphatic system disorders; Pyrexia; Platelet count decreased)

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