Basic Information

Gene symbol TNFRSF8 Synonyms CD30, D1S166E, Ki-1 Type of gene protein-coding
Description TNF receptor superfamily member 8

GTO ID GTC0109
Trial ID NCT01316146
Disease Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma
Altered gene CD30
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD30 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusWithdrawn
TitleAdministration of T Lymphocytes for Hodgkin's Lymphoma and Non-Hodgkin's Lymphoma (CART CD30)
Year2011
CountryUnited States
Company sponsorUNC Lineberger Comprehensive Cancer Center
Other ID(s)LCCC 1544-ATL|H-27721-CART CD30
Vector information
Vectorretrovirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2E7 cells/m^2, 1E8 cells/m^2, 2E8 cells/m^2
Donor type Autologous
Pts 9
Age Child, Adult, Older_Adult
Lymph depletion No
Outcome 3/9(CR); 3/9(SD)
Adverse reactions no any CAR-T-related severe events

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