Basic Information

Gene symbol FURIN Synonyms FUR, PACE, PCSK3, SPC1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description furin, paired basic amino acid cleaving enzyme

Gene symbol TGFB1 Synonyms CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description transforming growth factor beta 1

Gene symbol TGFB2 Synonyms G-TSF, LDS4, TGF-beta2 Type of gene protein-coding
Description transforming growth factor beta 2

GTO ID GTC0108
Trial ID NCT01309230
Disease Ovarian Cancer
Altered gene FURIN|TGFB1|TGFB2
Therapeutic/Target gene Target gene
TherapyshRNA
Treatment Vigil|FANG Vaccine
PhasePhase2
Recruitment statusCompleted
TitleOpen-label Phase II Trial of Adjuvant bishRNAfurin and GMCSF Augmented Autologous Tumor Cell Vaccine (FANG) for High Risk Stage III/IV Ovarian Cancer
Year2011
CountryUnited States
Company sponsorGradalis, Inc.
Other ID(s)CL-PTL 105

Clinical Result

Cohort1: Vigil
Administration route intradermal injection
Dosage Vigil, 1E7 cells/injection, minimum of 4 doses and a maximum of 12 doses
Pts 28
Age Adult, Older_Adult
Outcome Time to Recurrence (TTR):18.2 (14.7 to 43.4)
Adverse reactions 20/28(All-cause mortality); 3/28(General disorders; Infections and infestations)
Cohort2: Standard of Care
Administration route None
Pts 11
Age Adult, Older_Adult
Outcome Time to Recurrence (TTR):12.4 (10.2 to NA)
Adverse reactions 7/11(All-cause mortality)

Relationship Graph

Overview of Knowledge Graph