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Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	IFNA2	Synonyms	IFN-alpha-2, IFN-alphaA, IFNA, IFNA2B, leIF A	Type of gene	protein-coding
Chromosome	9	Map location	9p21.3	dbXrefs
Description	interferon alpha 2

GTO ID	GTC0102
Trial ID	NCT01212367
Disease	Malignant Pleural Mesothelioma
Altered gene	IFNA2
Therapeutic/Target gene	Therapeutic gene
Therapy	Gene transfer
Treatment	SCH 721015
Phase	Phase1
Recruitment status	Completed
Title	A Pilot Study of Repeated Dose Intrapleural Adenoviral-Mediated Interferon-Alpha (SCH 721015, Ad.HIFN-a2b) Gene Transfer for Malignant Pleural Mesothelioma
Year	2010
Country	United States
Company sponsor	Abramson Cancer Center at Penn Medicine
Other ID(s)	UPCC 18508; 808806\|P01CA066726

Vector information

Vector	adenovirus
Construct	Ad.hIFN-α2b
Vector type	clinical-grade, serotype 5, E1/partial E3-deleted replication-incompetent adenovirus vector
Transgene/Inserted gene	human interferon-alpha2b gene
Viral genome modification	The E1 and partial E3 regions of the parental adenovirus DNA are deleted, with the insertion of the human IFN-α2b gene in the E1 region of the adenoviral genome.

Clinical Result

Cohort1: dose level 1

Administration route	intrapleural injection
Dosage	1E12 vp on Days 1 and 4
Pts	3
Age	Adult, Older_Adult
Outcome	2/3(PD)
References	PMID: 21642245

Cohort2: dose level 2

Administration route	intrapleural injection
Dosage	3E11 vp on Days 1 and 4
Pts	6
Age	Adult, Older_Adult
Outcome	1/6(PR); 2/6(SD); 3/6(not available)
References	PMID: 21642245

Relationship Graph

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