Detail

Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	tat	Synonyms	None	Type of gene	protein-coding
Chromosome	-	Map location	NC_001802.1 (5377..7970)	dbXrefs
Description	Tat

Gene symbol	vpr	Synonyms	None	Type of gene	protein coding
Chromosome	-	Map location	NC_001802.1 (5105..5396)	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas
Description	Vpr

GTO ID	GTC0099
Trial ID	NCT01177059
Disease	HIV-1 Infection
Altered gene	tat\|vpr
Therapeutic/Target gene	Target gene
Therapy	Ribozyme
Treatment	anti-HIV-1 Ribozyme [OZ1]
Phase	Phase2
Recruitment status	Completed
Title	A Long Term Follow-up Protocol to Evaluate the Safety and Survival of Autologous CD34+ Hematopoietic Progenitor Cells Transduced With an Anti-HIV-1 Ribozyme (OZ1) in Patients With HIV-1 Infection
Year	2004
Country	United States\|Australia
Company sponsor	Janssen-Cilag Pty Ltd
Other ID(s)	CR016027\|OZ1-HV1-202

Vector information

Vector	retrovirus

Clinical Result

Cohort 1

Administration route	None
Pts	68
Age	Child, Adult, Older_Adult
Outcome	Percentage of Participants With Clonal Expansion of Cells With a Predominant OZ1 Insertion Site:0\|Percentage of Participants With Insertional Oncogenesis:0\|Number of Participants With Quantitative Marking of Gene Transfer Product in Peripheral Blood Mononuclear Cells (PBMC) Over Time:
Adverse reactions	0/68(All-cause mortality); 7/68(Injury, poisoning and procedural complications; Neoplasms benign, malignant and unspecified(incl cysts and polyps); Pregnancy, puerperium and perinatal conditions; Psychiatric disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)

Relationship Graph

Overview of Knowledge Graph