Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC0097
Trial ID NCT01174095
Disease Coronary Artery Disease
Altered gene VEGFA
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV-VEGF121
Recruitment statusCompleted
TitleA Post Ten Year Follow up Assessment of a Phase I Trial of Angiogenic Gene Therapy for the Treatment of Coronary Artery Disease Using Direct Intramyocardial Administration of an Adenovirus Vector Expressing the VEGF121 cDNA
Year2010
CountryUnited States
Company sponsorWeill Medical College of Cornell University
Other ID(s)905010396
Vector information
Vectoradenovirus
ConstructAd-GVVEGF121.10
Vector typereplication-deficient adenovirus serotype 5 vector
Transgene/Inserted gene121 isoform of vascular endothelial growth factor (VEGF)
Regulatory elementa cytomegalovirus early/immediate enhancer/promoter; an artificial splice sequence; the simian virus 40 (SV40) poly (A)/stop signal
Viral genome modificationThe E1 and E3 regions of the parental adenovirus DNA are deleted.

Clinical Result

Cohort1: dose level 1
Administration route subepicardial injection
Dosage 4E8~4E10 PU
Pts 15
Age Adult, Older_Adult
Outcome survival at 5 and 10 years was 10 of 15 (67%) and 6 of 15 (40%). For the survivors, the angina score was 3.4±0.5 at time 0 and 1.9±1.0 at last follow-up.
References PMID: 23137122
Cohort2: dose level 2
Administration route subepicardial injection
Dosage 4E9 PU
Pts 16
Age Adult, Older_Adult
Outcome survival at 5 and 10 years was 11 of 16 (69%) and 5 of 16 (31%). For the survivors, the angina score was 3.4±0.6 at time 0 and 2.0±1.1 at last follow-up.
References PMID: 23137122

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