Basic Information

Gene symbol IFNA2 Synonyms IFN-alpha-2, IFN-alphaA, IFNA, IFNA2B, leIF A Type of gene protein-coding
Description interferon alpha 2

GTO ID GTC0096
Trial ID NCT01119664
Disease Mesothelioma
Altered gene IFNA2B
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment SCH 721015
PhasePhase1
Recruitment statusCompleted
TitleA Pilot And Feasibility Trial Evaluating Two Different Chemotherapy Regimens In Combination With Intrapleural Adenoviral-Mediated Interferon-Alpha Gene Transfer For Malignant Pleural Mesothelioma
Year2010
CountryUnited States
Company sponsorAbramson Cancer Center at Penn Medicine
Other ID(s)UPCC 02510; 811318
Vector information
Vectoradenovirus
ConstructAd.hIFN-α2b
Vector typeclinical-grade, serotype 5, E1/partial E3-deleted replication-incompetent adenovirus vector
Transgene/Inserted genehuman interferon-alpha2b gene
Viral genome modificationThe E1 and partial E3 regions of the parental adenovirus DNA are deleted, with the insertion of the human IFN-α2b gene in the E1 region of the adenoviral genome.

Clinical Result

Cohort 1
Administration route intrapleural injection
Dosage 3E11 vp
Pts 40
Age Adult, Older_Adult
Outcome 25/40(SD); 10/40(PR); 5/40(PD)
Adverse reactions 2/40(Hemoglobin - low); 17/40(Lymphopenia); 2/40(Neutrophils - low); 1/40(Supraventricular tachycardia); 1/40(Tumor site worsen); 1/40(Hypoxia)
References PMID: 26968202

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