Basic Information

Gene symbol PKN3 Synonyms UTDP4-1 Type of gene protein-coding
Description protein kinase N3

GTO ID GTC0087
Trial ID NCT00938574
Disease Advanced Solid Tumor
Altered gene PKN3
Therapeutic/Target gene Target gene
TherapysiRNA
Treatment Atu027
PhasePhase1
Recruitment statusCompleted
TitleA Prospective, Open-label, Single Center, Dose Finding Phase I-study With Atu027 (an siRNA Formulation) in Subjects With Advanced Solid Cancer
Year2009
CountryGermany
Company sponsorSilence Therapeutics GmbH
Other ID(s)Atu027-I-01|EudraCT-No: 2008-005588-32
Vector information
Vectorliposome

Clinical Result

Cohort 1
Administration route intravenous injection
Pts 34
Age Adult, Older_Adult
Outcome Determination of dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of single and repeated intravenous infusion with Atu027 in subjects with advanced solid tumors:An MTD was not reached, given that only a single DLT was documented at DL10. This patientwith pancreatic cancer experienced a grade 3AE (increasedlipase),which was judged to be possibly related to Atu027 treatment
References PMID: 25403217

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