Detail

Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	CEACAM5	Synonyms	CD66e, CEA	Type of gene	protein-coding
Chromosome	19	Map location	19q13.2	dbXrefs
Description	CEA cell adhesion molecule 5

GTO ID	GTC0085
Trial ID	NCT00923806
Disease	Metastatic Melanoma
Altered gene	CEA
Therapeutic/Target gene	Target gene
Therapy	TCR-T cell
Treatment	CEA TCR-T cells
HLA	HLA-A*02:01
Phase	Phase1
Recruitment status	Terminated
Title	Phase I/II Study of Metastatic Cancer That Expresses Carcinoembryonic Antigen (CEA) Using Lymphodepleting Conditioning Followed by Infusion of Anti-CEA TCR-Gene Engineered Lymphocytes
Year	2009
Country	United States
Company sponsor	National Cancer Institute (NCI)
Other ID(s)	090047\|09-C-0047

Vector information

Vector	retrovirus
Transgene/Inserted gene	both α and β chains of the CEA-reactive murine TCR
Viral genome modification	A retroviral vector encoding both α and β chains of the CEA-reactive murine TCR separated by a picornavirus ribosomal skip element was constructed using an MSGV1 backbone.
Vector production method	Patient peripheral blood mononuclear cells were stimulated with anti-CD3 monoclonal antibody (OKT-3) and were transduced 2 days later with retroviral particles immobilized on retronectin (Takara Bio, Japan)-coated plates.

Clinical Result

Cohort 1

Administration route	infusion
Dosage	2~4E8 cells
Donor type	autologous
Pts	3
Age	Adult, Older_Adult
Lymph depletion	Yes
Outcome	3/3(CR)
Adverse reactions	3/3(severe colitis)
References	PMID: 21157437

Relationship Graph

Overview of Knowledge Graph