Basic Information

Gene symbol MLANA Synonyms MART-1, MART1 Type of gene protein-coding
Description melan-A

GTO ID GTC0083
Trial ID NCT00910650
Disease Melanoma
Altered gene MART-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment MAGE-A1 F5 TCR-T cells
HLAHLA-A*02:01
PhasePhase2
Recruitment statusCompleted
TitleAdoptive Transfer of MART-1 F5 TCR Engineered Peripheral Blood Mononuclear Cells (PBMC) After a Nonmyeloablative Conditioning Regimen, With Administration of MART-126·35-Pulsed Dendritic Cells and Interleukin-2, in Patients With Advanced Melanoma
Year2009
CountryUnited States
Company sponsorJonsson Comprehensive Cancer Center
Other ID(s)10-001212|08-02-020
Vector information
Vectorretrovirus
Transgene/Inserted geneanti-MART-1 F5 TCR genes

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.06~1E10 cells
Donor type autologous
Pts 14
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 6/13(PD); 7/13(SD)
Adverse reactions 14/14(All-cause mortality); 5/14(Cardiac disorders; Nervous system disorders; Renal and urinary disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)
References PMID: 24634374

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