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Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	CD40LG	Synonyms	CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L	Type of gene	protein-coding
Chromosome	X	Map location	Xq26.3	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas \| PertOrg
Description	CD40 ligand

GTO ID	GTC0082
Trial ID	NCT00891748
Disease	Bladder Cancer
Altered gene	CD40L
Therapeutic/Target gene	Therapeutic gene
Therapy	Gene transfer
Treatment	AdV-CD40L
Phase	Phase1\|Phase2
Recruitment status	Completed
Title	A Phase I/IIa Study of Dose-escalating Intravesical AdCD40L Instillation in Urinary Bladder Carcinoma
Year	2009
Country	Sweden
Company sponsor	Uppsala University
Other ID(s)	001:CD40L\|2006-000985-34

Vector information

Vector	adenovirus
Construct	AdV-RSV-CD40L
Vector type	adenoviral serotype 5 (Ad5) vector
Transgene/Inserted gene	human CD40 ligand (CD40L) gene
Regulatory element	a Rous sarcoma virus (RSV) promoter
Viral genome modification	The E1 and E3 regions of the parental adenovirus DNA are deleted.

Clinical Result

Cohort 1

Administration route	intravesical instillation
Dosage	1E12 vp/mL and 1.44E10 infectious units/mL
Pts	8
Age	Adult, Older_Adult
Outcome	Histologic evaluation indicated that AdCD40L therapy reduced the load of malignant cells.
Adverse reactions	1/1(postoperative pain following cystectomy); 3/8(postoperative infection); 1/1(asystole); 1/1(insomnia); 1/1(headache); 1/1(constipation); 1/1(common cold); 1/1(torticollis); 1/1(increased neutrophils and monocytes); 1/1(septicemia); 1/1(anorexia); 1/1(nausea)
References	PMID: 20448220

Relationship Graph

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