Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC0078
Trial ID NCT00858208
Disease Age-Related Macular Degeneration
Altered gene VEGFA
Therapeutic/Target gene Target gene
TherapyAptamer
Treatment Macugen|pegaptanib|EYE001
Recruitment statusCompleted
TitleLong-Term Non-Interventional Study To Investigate The Efficacy And Safety Of MACUGEN In Patients With Neovascular Age-Related Macular Degeneration Under Conditions Of Routine Clinical Practice
Year2008
CountryGreece
Company sponsorPfizer
Other ID(s)A5751028

Clinical Result

Cohort 1
Administration route intravitreal injection
Dosage pegaptanib sodium, every 6 weeks for 2 years
Pts 86
Age Adult, Older_Adult
Outcome Change From Baseline Visual Acuity (VA) at the Final Visit:aseline Mean (Standard Deviation):0.829(0.367); Change at Week 102/ET:-0.126(0.371)
Adverse reactions 1/85(Gastrointestinal disorders)

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