Basic Information

Gene symbol gag Synonyms None Type of gene protein-coding
Description Pr55(Gag)

Gene symbol S100B Synonyms NEF, S100, S100-B, S100beta Type of gene protein-coding
Description S100 calcium binding protein B

GTO ID GTC0074
Trial ID NCT00833781
Disease HIV Infection
Altered gene gag|nef
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment mRNA-transfected dendritic cells
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA Pilot, Double-blind, Placebo-controlled, Randomized Clinical Trial of mRNA-transfected Autologous Dendritic Cells in Subjects With Well-controlled Chronic HIV-1 Infection on Highly Active Antiretroviral Therapy
Year2009
CountryUnited States
Company sponsorMassachusetts General Hospital
Other ID(s)2008p001577|R01AI066992-04|DAIDS-ES ID 10731
Vector information
Vectordendritic cell

Clinical Result

Cohort1: mRNA transfected
Administration route intradermal injection
Dosage mRNA-transfected dendritic cells, weeks 0, 2, 6 and 10
Pts 10
Age Adult, Older_Adult
Outcome Safety of the DC Vaccine (as Measured by Frequency of Adverse Events): 0|Change From Baseline to Week 14 in ELISPOT Response to Gag and Nef: CD4 Gag proliferative response:2.465; CD4 Nef Proliferative: 2.292
Adverse reactions No serious clinical adverse events
References PMID: 26379068
Cohort2: no mRNA transfection
Administration route intradermal injection
Dosage Dendritic cells without mRNA, weeks 0, 2, 6 and 10
Pts 5
Age Adult, Older_Adult
Outcome Safety of the DC Vaccine (as Measured by Frequency of Adverse Events): 0|Change From Baseline to Week 14 in ELISPOT Response to Gag and Nef: CD4 Gag proliferative response:0.717; CD4 Nef Proliferative: 0.363
References PMID: 26379068

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