Basic Information

Gene symbol tk

GTO ID GTC0055
Trial ID NCT00638612
Disease Pancreatic Cancer
Altered gene tk
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV-tk
Co-treatment Valacyclovir
PhasePhase1
Recruitment statusCompleted
TitleAdV-tk + Valacyclovir Therapy in Combination With Surgery and Chemoradiation for Pancreas Cancer
Year2008
CountryUnited States
Company sponsorCandel Therapeutics, Inc.
Other ID(s)PaTK01
Vector information
Vectoradenovirus
ConstructAdv.RSV-HSV-tk
Vector typeadenoviral vector
Transgene/Inserted geneherpes simplex virus (HSV) thymidine kinase gene
Regulatory elementthe Rous sarcoma virus (RSV) long terminal repeat promoter

Clinical Result

Cohort 1
Administration route intratumoral injection
Dosage 3E10 vp, 1E11 vp, 3E11 vp, 1E12 vp
Pts 24
Age Adult, Older_Adult
Outcome 8/24(resected); 3/24(PR); 5/24(PD); 7/24(SD); 1/24(Not Evaluated)
Adverse reactions 3/24(Elevated bilirubin); 1/24(Elevated lipase); 2/24(Elevated lipase); 7/24(Elevated lipase)
References PMID: 25795132 | 8159705

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