Basic Information

Gene symbol MLANA Synonyms MART-1, MART1 Type of gene protein-coding
Description melan-A

GTO ID GTC0053
Trial ID NCT00612222
Disease Metastatic Melanoma | Skin Cancer
Altered gene MART-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment MAGE-A1 F5 TCR-T cells
Co-treatment ALVAC gp100 Vaccine
HLAHLA-A*02:01
PhasePhase2
Recruitment statusTerminated
TitlePhase II Study of Metastatic Melanoma Using Lymphodepleting Conditioning Followed by Infusion of Anti-MART-1 F5 TCR-Gene Engineered Lymphocytes and ALVAC Virus Immunization
Year2008
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)080056|08-C-0056
Vector information
Vectorretrovirus

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 0/4(ORR)
Adverse reactions 1/4(hearing test abnormal); 1/4(uveitis); 1/4(dizziness)

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