Basic Information

Gene symbol tk

GTO ID GTC0047
Trial ID NCT00589875
Disease Brain Glioma
Altered gene tk
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment CAN-2409|aglatimagene besadenove
Co-treatment Valacyclovir|Temozolomide|Radiation therapy
PhasePhase2
Recruitment statusCompleted
TitleA Phase IIa Study of AdV-tk + Valacyclovir Gene Therapy in Combination With Standard Radiation Therapy for Malignant Gliomas
Year2007
CountryUnited States
Company sponsorCandel Therapeutics, Inc.
Other ID(s)BrTK02
Vector information
Vectoradenovirus
ConstructAdV-tk
Vector typeadenoviral serotype 5 replication-defective engineered gene construct
Transgene/Inserted geneherpes simplex virus (HSV) thymidine kinase gene

Clinical Result

Cohort 1
Administration route injection
Dosage 3E11 vp
Pts 48
Age Adult, Older_Adult
Outcome Median overall survival (OS) was 17.1 months(P = .0417). Survival at 1, 2, and 3 years was 67%, 35%, and 19%. The greatest benefit was observed in gross total resection patients: median OS of 25 versus 16.9 months (P = .0492); 1, 2, and 3-year survival of 90%, 53%, and 32%.
Adverse reactions fever; fatigue; headache
References PMID: 26843484

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