Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC0033
Trial ID NCT00406107
Disease Retinal Vein Occlusion
Altered gene VEGFA
Therapeutic/Target gene Target gene
TherapyAptamer
Treatment Macugen|pegaptanib|EYE001
PhasePhase4
Recruitment statusCompleted
TitleOpen Label Macugen for the Treatment of Macular Edema Secondary to Branch Retinal Vein Occlusion
Year2006
CountryUnited States
Company sponsorPalmetto Retina Center, LLC
Other ID(s)PRC-001|Pfizer Reference # 20050548

Clinical Result

Cohort1: Macugen_dose level 1
Administration route intravitreal injection
Dosage pegaptanib, 0.3mg, baseline, week 6 and week 12 with subsequent injections at six weekly intervals at the discretion of the investigator until week 54
Pts 15
Age Adult, Older_Adult
Adverse reactions No serious clinical adverse events
Cohort2: Macugen_dose level 2
Administration route intravitreal injection
Dosage pegaptanib, 1mg, baseline, week 6 and week 12 with subsequent injections at six weekly intervals at the discretion of the investigator until week 54
Pts 5
Age Adult, Older_Adult
Adverse reactions No serious clinical adverse events

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