Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC0028
Trial ID NCT00324116
Disease Macular Degeneration
Altered gene VEGFA
Therapeutic/Target gene Target gene
TherapyAptamer
Treatment Macugen|pegaptanib|EYE001
PhasePhase4
Recruitment statusCompleted
TitleA Prospective, Open-Label Multi Center Trial Evaluating The Safety And Efficacy Of 0.3 Mg/Eye Pegaptanib Sodium (Macugen) Intravitreous Injection Given Every 6 Weeks For 54 Weeks In Patients With Small Neovascular Age-Related Macular Degeneration (AMD) Lesions
Year2006
CountryFrance
Company sponsorPfizer
Other ID(s)A5751016

Clinical Result

Cohort 1
Administration route intravitreal injection
Dosage pegaptanib, 0.3 MG/eye, every 6 weeks for 54 weeks
Pts 81
Age Adult, Older_Adult
Outcome Number of Responders for Visual Acuity Using Early Treatment Diabetic Retinopathy Study (ETDRS):Responders Measure Type: Number:40; Non-Responders:7; Censored (subjects with missing data):33
Adverse reactions 8/81(Cardiac disorders; Eye disorders; Gastrointestinal disorders; Infections and infestationsp; Psychiatric disorders)

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