Basic Information

Gene symbol IL12A Synonyms CLMF, IL-12A, NFSK, NKSF1, P35 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 12A

Gene symbol IL12B Synonyms CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2 Type of gene protein-coding
Description interleukin 12B

GTO ID GTC0027
Trial ID NCT00323206
Disease Malignant Adenoma
Altered gene IL-12A|IL-12B
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment pIL-12
Recruitment statusCompleted
TitlePhase I Trial of Intratumoral pIL-12 Electroporation in Malignant Melanoma
Year2006
CountryUnited States
Company sponsorH. Lee Moffitt Cancer Center and Research Institute
Other ID(s)MCC-13224
Vector information
Vectorplasmid

Clinical Result

Cohort1: dose level 1
Administration route intratympanic injection
Dosage 0.1 mg/mL
Pts 3
Age Adult, Older_Adult
Outcome 1/3(CR); 2/3(PR)
Adverse reactions ransient pain during the electroporation procedure; bleeding around the treatment site
References PMID: 19029422
Cohort2: dose level 2
Administration route intratympanic injection
Dosage 0.25 mg/mL
Pts 3
Age Adult, Older_Adult
Outcome 1/3(CR); 2/3(PR)
Adverse reactions ransient pain during the electroporation procedure; bleeding around the treatment site
References PMID: 19029422
Cohort3: dose level 3
Administration route intratympanic injection
Dosage 0.5 mg/mL
Pts 3
Age Adult, Older_Adult
Outcome 2/3(CR); 1/3(PR)
Adverse reactions ransient pain during the electroporation procedure; bleeding around the treatment site
References PMID: 19029422
Cohort4: dose level 4
Administration route intratympanic injection
Dosage 1.0 mg/mL
Pts 3
Age Adult, Older_Adult
Outcome 1/3(CR); 2/3(PR)
Adverse reactions ransient pain during the electroporation procedure; bleeding around the treatment site
References PMID: 19029422
Cohort5: dose level 5
Administration route intratympanic injection
Dosage 1.6 mg/mL
Pts 12
Age Adult, Older_Adult
Outcome 9/12(CR); 3/12(PR)
Adverse reactions ransient pain during the electroporation procedure; bleeding around the treatment site
References PMID: 19029422

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