Basic Information

Gene symbol CSF2 Synonyms CSF, GMCSF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description colony stimulating factor 2

GTO ID GTC0026
Trial ID NCT00289016
Disease Melanoma
Altered gene GMCSF
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment Talimogene Laherparepvec|Imlygic|T-VEC|JS1 34.5-hGMCSF 47- pA-
PhasePhase2
Recruitment statusCompleted
TitleA Phase II Study of the Efficacy, Safety and Immunogenicity of OncoVEX^GM-CSF in Patients With Stage IIIc and Stage IV Malignant Melanoma
Year2006
CountryUnited Kingdom|United States
Company sponsorBioVex Limited
Other ID(s)002/03
Vector information
Vectorherpes simplex virus

Clinical Result

Cohort 1
Administration route intratumoral injection
Dosage Up to 4 mL of 10^8 pfu/mL/per
Pts 50
Age Adult, Older_Adult
Outcome 28/50(OR)
Adverse reactions 17/50(Blood and lymphatic system disorders; Cardiac disorders; Gastrointestinal disorders; General disorders; Infections and infestations; Injury, poisoning and procedural complications; Neoplasms benign, malignant and unspecified, incl cysts and polyps; Nervous system disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)

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