Basic Information

Gene symbol CLU Synonyms AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2 Type of gene protein-coding
Description clusterin

GTO ID GTC0018
Trial ID NCT00138658
Disease Lung Non-Small Cell Carcinoma
Altered gene CLU
Therapeutic/Target gene Target gene
TherapyASO
Treatment OGX-011|custirsen sodium|TV-1011
Co-treatment Gemcitabine|cisplatin|carboplatin
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA Phase 1-2 Study of Weekly OGX-011 Plus a Gemcitabine/Platinum-Based Regimen in Patients With Stage IIIB or IV Non Small Cell Lung Cancer
Year2004
CountryUnited States|Canada
Company sponsorAchieve Life Sciences
Other ID(s)OGX-011-05
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage Custirsen, 640 mg/480 mg, 2 hours weekly on Days 1, 8, and 15 of a 21-day cycle
Pts 85
Age Adult, Older_Adult
Adverse reactions 32/81(Blood and lymphatic system disorders; Cardiac disorders; Congenital, familial and genetic disorders; Eye disorders; Gastrointestinal disorders; General disorders; Infections and infestations; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders; Nervous system disorders; Psychiatric disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)

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