Basic Information


GTO ID GTC0016
Trial ID NCT00085930
Disease Neuroblastoma
Altered gene GD2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment GD2 CAR-T cells
Generation1st
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleBlood T-Cells and EBV Specific CTLs Expressing GD-2 Specific Chimeric T Cell Receptors to Neuroblastoma Patients
Year2003
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)13149-NESTLES
Vector information
Vectorretrovirus
ConstructscFv-CD3ζ
Additional featureEBV Specific

Clinical Result

Cohort 1
Administration route infusion
Dosage 2E7 cells/m^2, 5E7 cells/m^2, 1E8 cells/m^2
Donor type Autologous
Pts 19
Age Child, Adult
Lymph depletion No
Outcome 11/19(CR); 1/19(PR); 1/19(SD); 4/19(PD)
Adverse reactions 3/19(localized pain)
References PMID: 21984804

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