Basic Information

Gene symbol BCL2 Synonyms Bcl-2, PPP1R50 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description BCL2 apoptosis regulator

GTO ID GTC0015
Trial ID NCT00085228
Disease Prostate Cancer
Altered gene Bcl-2
Therapeutic/Target gene Target gene
TherapyASO
Treatment Genasense|G3139|oblimersen sodium
Co-treatment docetaxel
PhasePhase2
Recruitment statusCompleted
TitleRandomized Phase II Trial of Docetaxel (Taxotere) and Oblimersen (Antisense Oligonucleotide Directed to BCL-2) Versus Taxotere Alone in Patients With Hormone-Refractory Prostate Cancer
Year2004
CountryAustria|Belgium|Denmark|France|Israel|Italy|Netherlands|Poland|Portugal|Spain|United Kingdom
Company sponsorEuropean Organisation for Research and Treatment of Cancer - EORTC
Other ID(s)EORTC-30021|EORTC-30021|AVENTIS-AVE3139E/2501
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Pts 54
Age Adult, Older_Adult
Outcome 10/49(PR); 22/49(SD)
Adverse reactions fatigue, mucositis, thrombocytopenia
References PMID: 19297314

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