Basic Information

Gene symbol IFNB1 Synonyms IFB, IFF, IFN-beta, IFNB Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description interferon beta 1

GTO ID GTC0014
Trial ID NCT00066404
Disease Malignant Pleural Mesothelioma | Malignant Pleural Effusion
Altered gene IFNB
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment BG00001|IDEC-201
PhasePhase1
Recruitment statusCompleted
TitleA Phase I Clinical Trial of Intrapleural Adenoviral-Mediated Interferon-beta (IFN-β) Gene Transfer for Pleural Malignancies
Year2003
CountryUnited States
Company sponsorAbramson Cancer Center at Penn Medicine
Other ID(s)CDR0000315899|UPCC-01502
Vector information
Vectoradenovirus
ConstructrAd-hIFN-beta
Vector typerecombinant adenovirus vector
Transgene/Inserted genehuman IFN-β gene
Regulatory elementhuman cytomegalovirus (CMV) promoter
Viral genome modificationThe E1 and E3 regions of the parental adenovirus DNA are deleted, with the insertion of the human IFN-β gene in the E1 region of the adenoviral genome.

Clinical Result

Cohort1: dose level 1
Administration route intrapleural injection
Dosage 3E11 vp
Pts 4
Age Adult, Older_Adult
Outcome 1/4(PR); 3/4(PD)
References PMID: 20068553
Cohort2: dose level 2
Administration route intrapleural injection
Dosage 1E12 vp
Pts 6
Age Adult, Older_Adult
Outcome 3/6(SD); 3/6(PD)
References PMID: 20068553
Cohort3: dose level 3
Administration route intrapleural injection
Dosage 3E12 vp
Pts 7
Age Adult, Older_Adult
Outcome 1/7(SD); 3/7(PD)
Adverse reactions 1/7(dyspnea; vomit; pericardial tamponade)
References PMID: 20068553

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