Basic Information

Gene symbol BCL2 Synonyms Bcl-2, PPP1R50 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description BCL2 apoptosis regulator

GTO ID GTC0013
Trial ID NCT00063934
Disease Breast Cancer
Altered gene Bcl-2
Therapeutic/Target gene Target gene
TherapyASO
Treatment Genasense|G3139|oblimersen sodium
Co-treatment doxorubicin hydrochloride|docetaxel|filgrastim|pegfilgrastim|therapeutic conventional surgery
PhasePhase1|Phase2
Recruitment statusTerminated
TitleA Phase 1/2 Study of Bcl-2 Antisense Oligonucleotide G3139 in Combination With Doxorubicin and Docetaxel in Metastatic and Locally Advanced Breast Cancer
Year2003
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)NCI-2012-02885|NCI-2012-02885|6023|DM02-700|6023|P30CA016672|N01CM17003
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Pts 30
Age Adult, Older_Adult
Outcome 30/30(CR)
Adverse reactions 1/30(All-cause mortality); 30/30(Blood and lymphatic system disorders; Cardiac disorders; Endocrine disorders; Gastrointestinal disorders; Gastrointestinal disorders; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders)

Relationship Graph

Overview of Knowledge Graph