Basic Information

Gene symbol BCL2 Synonyms Bcl-2, PPP1R50 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description BCL2 apoptosis regulator

GTO ID GTC0008
Trial ID NCT00021749
Disease Chronic Lymphocytic Leukemia
Altered gene Bcl-2
Therapeutic/Target gene Target gene
TherapyASO
Treatment Genasense|G3139|oblimersen sodium
PhasePhase1|Phase2
Recruitment statusCompleted
TitlePhase I-II Multicenter Study of Genasense (Bcl-2 Antisense Oligonucleotide) in Patients With Advanced Chronic Lymphocytic Leukemia
Year2001
CountryUnited States
Company sponsorGenta Incorporated
Other ID(s)GL208|G3139|Bcl-2 Antisense
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 3~7 mg/kg/d
Pts 40
Age Adult, Older_Adult
Outcome 2/26(PR)
Adverse reactions transient hypotension, fever, fatigue, night sweats, diarrhea, nausea, vomiting, hypokalemia, cough
References PMID: 16186597

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